Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.
Identifieur interne : 000C34 ( Main/Exploration ); précédent : 000C33; suivant : 000C35Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.
Auteurs : Sarah M. Lofgren ; Melanie R. Nicol ; Ananta S. Bangdiwala ; Katelyn A. Pastick ; Elizabeth C. Okafor ; Caleb P. Skipper ; Matthew F. Pullen ; Nicole W. Engen ; Mahsa Abassi ; Darlisha A. Williams ; Alanna A. Nascene ; Margaret L. Axelrod ; Sylvian A. Lother ; Lauren J. Mackenzie ; Glen Drobot ; Nicole Marten ; Matthew P. Cheng ; Ryan Zarychanshi ; Ilan S. Schwartz ; Michael Silverman ; Zain Chagla ; Lauren E. Kelly ; Emily G. Mcdonald ; Todd C. Lee ; Katherine Huppler Hullsiek ; David R. Boulware ; Radha RajasinghamSource :
- medRxiv : the preprint server for health sciences ; 2020.
Abstract
INTRODUCTION
Use of hydroxychloroquine in hospitalized patients with COVID-19, especially in combination with azithromycin, has raised safety concerns. Here, we report safety data from three outpatient randomized clinical trials.
METHODS
We conducted three randomized, double-blind, placebo-controlled trials investigating hydroxychloroquine as pre-exposure prophylaxis, post-exposure prophylaxis and early treatment for COVID-19. We excluded individuals with contraindications to hydroxychloroquine. We collected side effects and serious adverse events. We report descriptive analyses of our findings.
RESULTS
We enrolled 2,795 participants. The median age of research participants was 40 (IQR 34-49) years, and 59% (1633/2767) reported no chronic medical conditions. Overall 2,324 (84%) participants reported side effect data, and 638 (27%) reported at least one medication side effect. Side effects were reported in 29% with daily, 36% with twice weekly, 31% with once weekly hydroxychloroquine compared to 19% with placebo. The most common side effects were upset stomach or nausea (25% with daily, 18% with twice weekly, 16% with weekly, vs. 10% for placebo), followed by diarrhea, vomiting, or abdominal pain (23% for daily, 16% twice weekly, 12% weekly, vs. 6% for placebo). Two individuals were hospitalized for atrial arrhythmias, one on placebo and one on twice weekly hydroxychloroquine. No sudden deaths occurred.
CONCLUSION
Data from three outpatient COVID-19 trials demonstrated that gastrointestinal side effects were common but mild with the use of hydroxychloroquine, while serious side effects were rare. No deaths occurred related to hydroxychloroquine. Randomized clinical trials can safely investigate whether hydroxychloroquine is efficacious for COVID-19.
DOI: 10.1101/2020.07.16.20155531
PubMed: 32743591
PubMed Central: PMC7386515
Affiliations:
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Cheng</name></author><author><name sortKey="Zarychanshi, Ryan" sort="Zarychanshi, Ryan" uniqKey="Zarychanshi R" first="Ryan" last="Zarychanshi">Ryan Zarychanshi</name></author><author><name sortKey="Schwartz, Ilan S" sort="Schwartz, Ilan S" uniqKey="Schwartz I" first="Ilan S" last="Schwartz">Ilan S. Schwartz</name></author><author><name sortKey="Silverman, Michael" sort="Silverman, Michael" uniqKey="Silverman M" first="Michael" last="Silverman">Michael Silverman</name></author><author><name sortKey="Chagla, Zain" sort="Chagla, Zain" uniqKey="Chagla Z" first="Zain" last="Chagla">Zain Chagla</name></author><author><name sortKey="Kelly, Lauren E" sort="Kelly, Lauren E" uniqKey="Kelly L" first="Lauren E" last="Kelly">Lauren E. Kelly</name></author><author><name sortKey="Mcdonald, Emily G" sort="Mcdonald, Emily G" uniqKey="Mcdonald E" first="Emily G" last="Mcdonald">Emily G. Mcdonald</name></author><author><name sortKey="Lee, Todd C" sort="Lee, Todd C" uniqKey="Lee T" first="Todd C" last="Lee">Todd C. Lee</name></author><author><name sortKey="Hullsiek, Katherine Huppler" sort="Hullsiek, Katherine Huppler" uniqKey="Hullsiek K" first="Katherine Huppler" last="Hullsiek">Katherine Huppler Hullsiek</name></author><author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R" last="Boulware">David R. Boulware</name></author><author><name sortKey="Rajasingham, Radha" sort="Rajasingham, Radha" uniqKey="Rajasingham R" first="Radha" last="Rajasingham">Radha Rajasingham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32743591</idno><idno type="pmid">32743591</idno><idno type="doi">10.1101/2020.07.16.20155531</idno><idno type="pmc">PMC7386515</idno><idno type="wicri:Area/Main/Corpus">000F99</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F99</idno><idno type="wicri:Area/Main/Curation">000F99</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000F99</idno><idno type="wicri:Area/Main/Exploration">000F99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.</title><author><name sortKey="Lofgren, Sarah M" sort="Lofgren, Sarah M" uniqKey="Lofgren S" first="Sarah M" last="Lofgren">Sarah M. Lofgren</name></author><author><name sortKey="Nicol, Melanie R" sort="Nicol, Melanie R" uniqKey="Nicol M" first="Melanie R" last="Nicol">Melanie R. Nicol</name></author><author><name sortKey="Bangdiwala, Ananta S" sort="Bangdiwala, Ananta S" uniqKey="Bangdiwala A" first="Ananta S" last="Bangdiwala">Ananta S. Bangdiwala</name></author><author><name sortKey="Pastick, Katelyn A" sort="Pastick, Katelyn A" uniqKey="Pastick K" first="Katelyn A" last="Pastick">Katelyn A. Pastick</name></author><author><name sortKey="Okafor, Elizabeth C" sort="Okafor, Elizabeth C" uniqKey="Okafor E" first="Elizabeth C" last="Okafor">Elizabeth C. Okafor</name></author><author><name sortKey="Skipper, Caleb P" sort="Skipper, Caleb P" uniqKey="Skipper C" first="Caleb P" last="Skipper">Caleb P. Skipper</name></author><author><name sortKey="Pullen, Matthew F" sort="Pullen, Matthew F" uniqKey="Pullen M" first="Matthew F" last="Pullen">Matthew F. Pullen</name></author><author><name sortKey="Engen, Nicole W" sort="Engen, Nicole W" uniqKey="Engen N" first="Nicole W" last="Engen">Nicole W. Engen</name></author><author><name sortKey="Abassi, Mahsa" sort="Abassi, Mahsa" uniqKey="Abassi M" first="Mahsa" last="Abassi">Mahsa Abassi</name></author><author><name sortKey="Williams, Darlisha A" sort="Williams, Darlisha A" uniqKey="Williams D" first="Darlisha A" last="Williams">Darlisha A. Williams</name></author><author><name sortKey="Nascene, Alanna A" sort="Nascene, Alanna A" uniqKey="Nascene A" first="Alanna A" last="Nascene">Alanna A. Nascene</name></author><author><name sortKey="Axelrod, Margaret L" sort="Axelrod, Margaret L" uniqKey="Axelrod M" first="Margaret L" last="Axelrod">Margaret L. Axelrod</name></author><author><name sortKey="Lother, Sylvian A" sort="Lother, Sylvian A" uniqKey="Lother S" first="Sylvian A" last="Lother">Sylvian A. Lother</name></author><author><name sortKey="Mackenzie, Lauren J" sort="Mackenzie, Lauren J" uniqKey="Mackenzie L" first="Lauren J" last="Mackenzie">Lauren J. Mackenzie</name></author><author><name sortKey="Drobot, Glen" sort="Drobot, Glen" uniqKey="Drobot G" first="Glen" last="Drobot">Glen Drobot</name></author><author><name sortKey="Marten, Nicole" sort="Marten, Nicole" uniqKey="Marten N" first="Nicole" last="Marten">Nicole Marten</name></author><author><name sortKey="Cheng, Matthew P" sort="Cheng, Matthew P" uniqKey="Cheng M" first="Matthew P" last="Cheng">Matthew P. Cheng</name></author><author><name sortKey="Zarychanshi, Ryan" sort="Zarychanshi, Ryan" uniqKey="Zarychanshi R" first="Ryan" last="Zarychanshi">Ryan Zarychanshi</name></author><author><name sortKey="Schwartz, Ilan S" sort="Schwartz, Ilan S" uniqKey="Schwartz I" first="Ilan S" last="Schwartz">Ilan S. Schwartz</name></author><author><name sortKey="Silverman, Michael" sort="Silverman, Michael" uniqKey="Silverman M" first="Michael" last="Silverman">Michael Silverman</name></author><author><name sortKey="Chagla, Zain" sort="Chagla, Zain" uniqKey="Chagla Z" first="Zain" last="Chagla">Zain Chagla</name></author><author><name sortKey="Kelly, Lauren E" sort="Kelly, Lauren E" uniqKey="Kelly L" first="Lauren E" last="Kelly">Lauren E. Kelly</name></author><author><name sortKey="Mcdonald, Emily G" sort="Mcdonald, Emily G" uniqKey="Mcdonald E" first="Emily G" last="Mcdonald">Emily G. Mcdonald</name></author><author><name sortKey="Lee, Todd C" sort="Lee, Todd C" uniqKey="Lee T" first="Todd C" last="Lee">Todd C. Lee</name></author><author><name sortKey="Hullsiek, Katherine Huppler" sort="Hullsiek, Katherine Huppler" uniqKey="Hullsiek K" first="Katherine Huppler" last="Hullsiek">Katherine Huppler Hullsiek</name></author><author><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R" last="Boulware">David R. Boulware</name></author><author><name sortKey="Rajasingham, Radha" sort="Rajasingham, Radha" uniqKey="Rajasingham R" first="Radha" last="Rajasingham">Radha Rajasingham</name></author></analytic><series><title level="j">medRxiv : the preprint server for health sciences</title><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Use of hydroxychloroquine in hospitalized patients with COVID-19, especially in combination with azithromycin, has raised safety concerns. Here, we report safety data from three outpatient randomized clinical trials.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted three randomized, double-blind, placebo-controlled trials investigating hydroxychloroquine as pre-exposure prophylaxis, post-exposure prophylaxis and early treatment for COVID-19. We excluded individuals with contraindications to hydroxychloroquine. We collected side effects and serious adverse events. We report descriptive analyses of our findings.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We enrolled 2,795 participants. The median age of research participants was 40 (IQR 34-49) years, and 59% (1633/2767) reported no chronic medical conditions. Overall 2,324 (84%) participants reported side effect data, and 638 (27%) reported at least one medication side effect. Side effects were reported in 29% with daily, 36% with twice weekly, 31% with once weekly hydroxychloroquine compared to 19% with placebo. The most common side effects were upset stomach or nausea (25% with daily, 18% with twice weekly, 16% with weekly, vs. 10% for placebo), followed by diarrhea, vomiting, or abdominal pain (23% for daily, 16% twice weekly, 12% weekly, vs. 6% for placebo). Two individuals were hospitalized for atrial arrhythmias, one on placebo and one on twice weekly hydroxychloroquine. No sudden deaths occurred.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Data from three outpatient COVID-19 trials demonstrated that gastrointestinal side effects were common but mild with the use of hydroxychloroquine, while serious side effects were rare. No deaths occurred related to hydroxychloroquine. Randomized clinical trials can safely investigate whether hydroxychloroquine is efficacious for COVID-19.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32743591</PMID><DateRevised><Year>2020</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Electronic"><Journal><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>23</Day></PubDate></JournalIssue><Title>medRxiv : the preprint server for health sciences</Title><ISOAbbreviation>medRxiv</ISOAbbreviation></Journal><ArticleTitle>Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">2020.07.16.20155531</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1101/2020.07.16.20155531</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Use of hydroxychloroquine in hospitalized patients with COVID-19, especially in combination with azithromycin, has raised safety concerns. Here, we report safety data from three outpatient randomized clinical trials.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted three randomized, double-blind, placebo-controlled trials investigating hydroxychloroquine as pre-exposure prophylaxis, post-exposure prophylaxis and early treatment for COVID-19. We excluded individuals with contraindications to hydroxychloroquine. We collected side effects and serious adverse events. We report descriptive analyses of our findings.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We enrolled 2,795 participants. The median age of research participants was 40 (IQR 34-49) years, and 59% (1633/2767) reported no chronic medical conditions. Overall 2,324 (84%) participants reported side effect data, and 638 (27%) reported at least one medication side effect. Side effects were reported in 29% with daily, 36% with twice weekly, 31% with once weekly hydroxychloroquine compared to 19% with placebo. The most common side effects were upset stomach or nausea (25% with daily, 18% with twice weekly, 16% with weekly, vs. 10% for placebo), followed by diarrhea, vomiting, or abdominal pain (23% for daily, 16% twice weekly, 12% weekly, vs. 6% for placebo). Two individuals were hospitalized for atrial arrhythmias, one on placebo and one on twice weekly hydroxychloroquine. No sudden deaths occurred.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Data from three outpatient COVID-19 trials demonstrated that gastrointestinal side effects were common but mild with the use of hydroxychloroquine, while serious side effects were rare. No deaths occurred related to hydroxychloroquine. Randomized clinical trials can safely investigate whether hydroxychloroquine is efficacious for COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lofgren</LastName><ForeName>Sarah M</ForeName><Initials>SM</Initials><Identifier Source="ORCID">0000-0001-6717-2614</Identifier></Author><Author ValidYN="Y"><LastName>Nicol</LastName><ForeName>Melanie R</ForeName><Initials>MR</Initials><Identifier Source="ORCID">0000-0001-5513-5509</Identifier></Author><Author ValidYN="Y"><LastName>Bangdiwala</LastName><ForeName>Ananta S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Pastick</LastName><ForeName>Katelyn A</ForeName><Initials>KA</Initials><Identifier Source="ORCID">0000-0002-1306-1713</Identifier></Author><Author ValidYN="Y"><LastName>Okafor</LastName><ForeName>Elizabeth C</ForeName><Initials>EC</Initials><Identifier Source="ORCID">0000-0003-1495-4596</Identifier></Author><Author ValidYN="Y"><LastName>Skipper</LastName><ForeName>Caleb P</ForeName><Initials>CP</Initials><Identifier Source="ORCID">0000-0002-0000-8876</Identifier></Author><Author ValidYN="Y"><LastName>Pullen</LastName><ForeName>Matthew F</ForeName><Initials>MF</Initials><Identifier Source="ORCID">0000-0002-4644-7487</Identifier></Author><Author ValidYN="Y"><LastName>Engen</LastName><ForeName>Nicole W</ForeName><Initials>NW</Initials><Identifier Source="ORCID">0000-0003-1118-4194</Identifier></Author><Author ValidYN="Y"><LastName>Abassi</LastName><ForeName>Mahsa</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-9601-3006</Identifier></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Darlisha A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Nascene</LastName><ForeName>Alanna A</ForeName><Initials>AA</Initials><Identifier Source="ORCID">0000-0002-5622-5810</Identifier></Author><Author ValidYN="Y"><LastName>Axelrod</LastName><ForeName>Margaret L</ForeName><Initials>ML</Initials><Identifier Source="ORCID">0000-0003-4713-8798</Identifier></Author><Author ValidYN="Y"><LastName>Lother</LastName><ForeName>Sylvian A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>MacKenzie</LastName><ForeName>Lauren J</ForeName><Initials>LJ</Initials><Identifier Source="ORCID">0000-0002-4794-9120</Identifier></Author><Author ValidYN="Y"><LastName>Drobot</LastName><ForeName>Glen</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0002-0879-9668</Identifier></Author><Author ValidYN="Y"><LastName>Marten</LastName><ForeName>Nicole</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Matthew P</ForeName><Initials>MP</Initials><Identifier Source="ORCID">0000-0002-4867-2063</Identifier></Author><Author ValidYN="Y"><LastName>Zarychanshi</LastName><ForeName>Ryan</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Ilan S</ForeName><Initials>IS</Initials><Identifier Source="ORCID">0000-0002-7522-0281</Identifier></Author><Author ValidYN="Y"><LastName>Silverman</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Chagla</LastName><ForeName>Zain</ForeName><Initials>Z</Initials><Identifier Source="ORCID">0000-0002-3619-7031</Identifier></Author><Author ValidYN="Y"><LastName>Kelly</LastName><ForeName>Lauren E</ForeName><Initials>LE</Initials></Author><Author ValidYN="Y"><LastName>McDonald</LastName><ForeName>Emily G</ForeName><Initials>EG</Initials><Identifier Source="ORCID">0000-0003-0783-0624</Identifier></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Todd C</ForeName><Initials>TC</Initials><Identifier Source="ORCID">0000-0002-2267-4239</Identifier></Author><Author ValidYN="Y"><LastName>Hullsiek</LastName><ForeName>Katherine Huppler</ForeName><Initials>KH</Initials><Identifier Source="ORCID">0000-0002-2754-3473</Identifier></Author><Author ValidYN="Y"><LastName>Boulware</LastName><ForeName>David R</ForeName><Initials>DR</Initials><Identifier Source="ORCID">0000-0002-4715-0060</Identifier></Author><Author ValidYN="Y"><LastName>Rajasingham</LastName><ForeName>Radha</ForeName><Initials>R</Initials><Identifier Source="ORCID">0000-0001-5531-0231</Identifier></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS110519</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR002494</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 AI138851</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI125003</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AI055433</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>L30 TW011500</GrantID><Acronym>TW</Acronym><Agency>FIC NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 MH121220</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K08 AI134262</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D000076942">Preprint</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>medRxiv</MedlineTA><NlmUniqueID>101767986</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="UpdateIn"><RefSource>Open Forum Infect Dis. 2020 Oct 19;7(11):ofaa500</RefSource><PMID Version="1">33204764</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>4</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32743591</ArticleId><ArticleId IdType="doi">10.1101/2020.07.16.20155531</ArticleId><ArticleId IdType="pmc">PMC7386515</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Abassi, Mahsa" sort="Abassi, Mahsa" uniqKey="Abassi M" first="Mahsa" last="Abassi">Mahsa Abassi</name><name sortKey="Axelrod, Margaret L" sort="Axelrod, Margaret L" uniqKey="Axelrod M" first="Margaret L" last="Axelrod">Margaret L. Axelrod</name><name sortKey="Bangdiwala, Ananta S" sort="Bangdiwala, Ananta S" uniqKey="Bangdiwala A" first="Ananta S" last="Bangdiwala">Ananta S. Bangdiwala</name><name sortKey="Boulware, David R" sort="Boulware, David R" uniqKey="Boulware D" first="David R" last="Boulware">David R. Boulware</name><name sortKey="Chagla, Zain" sort="Chagla, Zain" uniqKey="Chagla Z" first="Zain" last="Chagla">Zain Chagla</name><name sortKey="Cheng, Matthew P" sort="Cheng, Matthew P" uniqKey="Cheng M" first="Matthew P" last="Cheng">Matthew P. Cheng</name><name sortKey="Drobot, Glen" sort="Drobot, Glen" uniqKey="Drobot G" first="Glen" last="Drobot">Glen Drobot</name><name sortKey="Engen, Nicole W" sort="Engen, Nicole W" uniqKey="Engen N" first="Nicole W" last="Engen">Nicole W. Engen</name><name sortKey="Hullsiek, Katherine Huppler" sort="Hullsiek, Katherine Huppler" uniqKey="Hullsiek K" first="Katherine Huppler" last="Hullsiek">Katherine Huppler Hullsiek</name><name sortKey="Kelly, Lauren E" sort="Kelly, Lauren E" uniqKey="Kelly L" first="Lauren E" last="Kelly">Lauren E. Kelly</name><name sortKey="Lee, Todd C" sort="Lee, Todd C" uniqKey="Lee T" first="Todd C" last="Lee">Todd C. Lee</name><name sortKey="Lofgren, Sarah M" sort="Lofgren, Sarah M" uniqKey="Lofgren S" first="Sarah M" last="Lofgren">Sarah M. Lofgren</name><name sortKey="Lother, Sylvian A" sort="Lother, Sylvian A" uniqKey="Lother S" first="Sylvian A" last="Lother">Sylvian A. Lother</name><name sortKey="Mackenzie, Lauren J" sort="Mackenzie, Lauren J" uniqKey="Mackenzie L" first="Lauren J" last="Mackenzie">Lauren J. Mackenzie</name><name sortKey="Marten, Nicole" sort="Marten, Nicole" uniqKey="Marten N" first="Nicole" last="Marten">Nicole Marten</name><name sortKey="Mcdonald, Emily G" sort="Mcdonald, Emily G" uniqKey="Mcdonald E" first="Emily G" last="Mcdonald">Emily G. Mcdonald</name><name sortKey="Nascene, Alanna A" sort="Nascene, Alanna A" uniqKey="Nascene A" first="Alanna A" last="Nascene">Alanna A. Nascene</name><name sortKey="Nicol, Melanie R" sort="Nicol, Melanie R" uniqKey="Nicol M" first="Melanie R" last="Nicol">Melanie R. Nicol</name><name sortKey="Okafor, Elizabeth C" sort="Okafor, Elizabeth C" uniqKey="Okafor E" first="Elizabeth C" last="Okafor">Elizabeth C. Okafor</name><name sortKey="Pastick, Katelyn A" sort="Pastick, Katelyn A" uniqKey="Pastick K" first="Katelyn A" last="Pastick">Katelyn A. Pastick</name><name sortKey="Pullen, Matthew F" sort="Pullen, Matthew F" uniqKey="Pullen M" first="Matthew F" last="Pullen">Matthew F. Pullen</name><name sortKey="Rajasingham, Radha" sort="Rajasingham, Radha" uniqKey="Rajasingham R" first="Radha" last="Rajasingham">Radha Rajasingham</name><name sortKey="Schwartz, Ilan S" sort="Schwartz, Ilan S" uniqKey="Schwartz I" first="Ilan S" last="Schwartz">Ilan S. Schwartz</name><name sortKey="Silverman, Michael" sort="Silverman, Michael" uniqKey="Silverman M" first="Michael" last="Silverman">Michael Silverman</name><name sortKey="Skipper, Caleb P" sort="Skipper, Caleb P" uniqKey="Skipper C" first="Caleb P" last="Skipper">Caleb P. Skipper</name><name sortKey="Williams, Darlisha A" sort="Williams, Darlisha A" uniqKey="Williams D" first="Darlisha A" last="Williams">Darlisha A. Williams</name><name sortKey="Zarychanshi, Ryan" sort="Zarychanshi, Ryan" uniqKey="Zarychanshi R" first="Ryan" last="Zarychanshi">Ryan Zarychanshi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C34 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C34 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32743591
|texte= Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32743591" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |